MMVD Study
The first international prospective study
dedicated to Multiple and Mixed Valvular Diseases
The MMVD Study is a prospective international registry designed to better understand how multiple and mixed valvular disease presents and evolves in real life. The study collects clinical information and multimodality imaging from patients across dozens of centers worldwide, allowing us to capture the full spectrum of this complex condition. By bringing together data from different countries and healthcare systems, the project aims to clarify current practices, identify prognostic markers, and support future evidence-based recommendations.
“Multiple and mixed valvular disease is a daily reality for clinicians, yet remains one of the least explored areas in valvular cardiology. With this study, we finally bring global attention and data to a condition that urgently needs it.”
Dr Théo Pezel
Lariboisière Hospital, AP-HP (Paris, France)
Lead Principal Investigator
The MMVD Study includes all consecutive patients referred to a Cardiovascular imaging Department with a diagnosis of at least one at least moderate valvular heart disease (VHD), and who meet the criteria for MMVD defined by multiple and/or mixed disease.
Our Global Network
The MMVD Study is powered by the enthusiasm and collaborative spirit of the Heart Imagers of Tomorrow (HIT) community of the EACVI. Young and experienced cardiovascular imagers have joined forces to build the first worldwide registry dedicated to multiple and mixed valvular disease.
This shared effort brings together centers from more than 20 countries, each contributing real-world data, diverse clinical perspectives, and unique imaging expertise. Together, we are creating an unprecedented global picture of MMVD — one that reflects how patients are assessed, imaged, and treated across different healthcare systems and cultures.
24
Countries
88
Participating Centres
6,924
Patients Included
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👆 Click on any marker to discover participating centers!
The EACVI-MMVD study is a large-scale, multicenter registry designed to investigate moderate and severe mitral regurgitation through advanced multimodality imaging. Our goal is to improve diagnostic accuracy, treatment strategies, and patient outcomes through comprehensive data collection and collaborative research.
Our study employs a robust methodological framework:
- Prospective and retrospective data collection from multiple international centres
- Comprehensive multimodality imaging assessment including echocardiography, cardiac MRI, and CT
- Long-term follow-up with standardized clinical endpoints
- Collaborative analysis with leading cardiovascular imaging experts
Mitral Regurgitation Assessment Using Multimodality Imaging
European Heart Journal - Cardiovascular Imaging • 2023
Prognostic Value of Advanced Imaging in Moderate MR
JACC: Cardiovascular Imaging • 2022
International Registry Design and Methodology
Circulation: Cardiovascular Imaging • 2021
University Hospital Paris
Paris, France
Dr. Marie Dubois
Charité Hospital
Berlin, Germany
Prof. Hans Schmidt
Oxford Heart Centre
Oxford, United Kingdom
Dr. James Thompson
Hospital San Raffaele
Milan, Italy
Prof. Giuseppe Rossi
Hospital Clínic Barcelona
Barcelona, Spain
Dr. Carmen García
Amsterdam UMC
Amsterdam, Netherlands
Dr. Jan van der Berg
For inquiries about collaboration, data access, or participation:
contact@mmvd-study.org